Wednesday, January 11, 2017

Uses and side effects of Calnif Retard tablets

Calnif retard is a prescription medication used to control hypertension, and to treat heart diseases (Angina). Its generic name is Nifedipine. Calnif retard is given orally. In addition, preparations that are put under the tongue is also available (for rapid reduction of blood pressure).

Calnif retard or slow release tablets

Retard means slow release. 

Retard means slow release. 

Do not crush or divide the medication, otherwise this will rapidly released into blood stream causing severe lowering of blood pressure. 

What your doctor consider when giving Calnif to you?

Some people with history of heart attacks should not be given this medication. So it is very important to mention whether you developed heart attacks before getting this medication.

If you got history of Heart attacks then mention that to your doctor

This medication should not be given, if heart pain (pain in left side of the chest) occurs or worsening of existing pain.

Doctors use this drug cautiously in patients with poor cardiac reserve, heart failure, severe hypotension, elderly patients, patients with diabetes mellitus, and hepatic impairment.

It is important to mention to your doctor whether you take medications for tuberculosis.

These medications given for Tuberculosis can have significant interactions with  Calnif

In addition, this drug should not be used for following conditions
1.     Cardiogenic shock
2.     Advanced aortic stenosis
3.     Porphyria
4.     Myocardial infarctions (heart attacks).

What are the common side effects of this medication?

Common side effects of Calnif

1.     Stomach upset
2.     Reduced blood pressure
3.     Increased heart rate
4.     Headache
5.     Dizziness
6.     Lethargy
7.     Lack of energy

What are the less common side effects of Calnif?

1.     Syncope (Sudden faint attacks)
2.     Nasal congestion.
3.     Shortness of breath
4.     Anxiety (Sudden terrible fearfulness)
5.     Sleep disturbance
6.     Migraine
7.     Pins and needles (paresthesia).
8.     Aggravation of migraine headaches
9.     Sleep problems
10. Passing increased amount of urine
11. Erectile dysfunction
12. Nose bleeds
13. Muscle pain

Hypersensitivity reactions can occur with some patients. They are hives, rashes, and itchiness, and yellowish discoloration of the body.

Rarely following side effects are reported. They include loss of appetite, swelling of the gums, mood abnormalities, hyperglycemia, and male infertility.

Skin rashes when exposed to sunlight (Photo sensitivity) reactions are also reported.

Difficulty in swallowing, intestinal obstruction, and intestinal ulcers has been reported. Increased sizes of the breasts, even in males can occur.

Very rarely Calnif causes agranulocytosis (reduction in all blood cells).


This medication can delay delivery of baby. So your doctor may not prescribe this medication during the pregnancy. It is sometimes used to delay delivery when the baby is premature.

This medication can delay Delivery of the baby

Breast feeding

Amount found in milk is too small to be harmful. But manufactures are advising doctors to avoid using Calnif, unless indicated.

This medication generally considered safe during breast feeding

Drug and food interactions

Patients should avoid taking grape fruit juice while taking Calnif. Grapefruit juice can increase plasma concentration of Calnif.

In addition, anti tuberculosis medication, Rifampicin reduces plasma concentration of this drug. Calnif can cause severe drop in the blood pressure, if co administered with beta blockers such as Tenormin.

Side effects can be reduced, if taken wholly with full glass of water without crushing or breaking the capsules.


AHFS Drug Information

British National Formulary

Use and common side effects Diaglip tablets

Diaglip® is a popular brand name of the prescription only oral antidiabetic agent Glipizide. This medication was developed by Cipla pharmaceuticals, India. Glipizide belongs to the sulfonylurea drug family.

 Diaglip® is one of the more potent anti-diabetic agents in the sulfonylurea family. This medication reduces blood glucose in both diabetic and non-diabetic individuals.

Diaglip tablets

What your doctor should know before prescribing?

Your doctor should know your complete medical history before prescribing Diaglip®. 

He should know whether you have liver problems and a condition called acute porphyria. If you have these problems doctor will not prescribe this medication for you. 

You should tell whether you have LIVER problems

The doctor will not prescribe this medication to you if you are pregnant or breast feeding. If you have renal impairment the doctor will analyze risks and benefits before starting on Diaglip®.

This medication should be taken as advised by the doctor. Also this should be taken as whole with a full glass of water to minimize side effects.

Take with full glass of water

Over dose can result in serious reduction of blood glucose and you should seek immediate medical advice. You need to check your blood glucose regularly during therapy to avoid changes in blood glucose levels in your blood.

Regular blood glucose level monitoring is essential

One of the important things is to take your recommended diabetic diet and reduce weight if you are overweight. Taking the medication and not following dietary advice is one of the main problem physicians face with their patients.

Healthy diabetic diet should accompany this medication. You should not eat sugar and take medication to compensate.

Important side effects of Diaglip

Reduction of blood glucose level is the main side effect of this medication as well.
Knowing the effects of reduced blood glucose is important.

Courtesy : 

"If you get these symptoms then you should take glucose or sugar snack and seek emergency medical help"

They are sweating, feeling hungry, and feeling that you are going to die and feeling faint.

Others will notice sudden changed behavior, impaired judgment, and confusion in you.

Doctors usually start on 2.5mg – 5mg daily shortly before breakfast or lunch.

How this medication works?

Diabetes is caused by destruction of beta cells (insulin producing cells) in the pancreas as well as increased insulin resistance. This medication acts by stimulating secretion of insulin from the existing beta cells of the pancreas. Diaglip® does not reduce peripheral insulin resistance.

 Since diabetes is a progressive disease, destruction of beta cells continues and the number of healthy beta cells goes down. So doctors have to increase the dose over time. Ultimately, the number of healthy beta cells will become so low, that doctors may need to discontinue the medication and start insulin injections. 


Diaglip is an anti diabetic medication manufactured in India. When you take the medication it is important to remember effects of reduced sugar in the body.